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This Concept Map, created with IHMC CmapTools, has information related to: therapy for pesticide and drug poisoning - paraquat, paraquat (bipyridyl class of herbicide) treatment removal unabsorbed paraquat, using: gastric lavage, actvd charcoal, paraquat (bipyridyl class of herbicide) sources herbicides (Agent Orange), paraquat (bipyridyl class of herbicide) signs and symptoms high amounts taken into lung epi cells via polyamine transporter, paraquat (bipyridyl class of herbicide) signs and symptoms fibrotic damage to lung, liver, and kidneys, paraquat (bipyridyl class of herbicide) treatment removal of absd: hemodialysis hemoperfusion serial actvd charcoal, paraquat is reduced and oxidized in cycle, between microsomal cytochrome C reductase and oxygen resulting in production of superoxide radicals, paraquat (bipyridyl class of herbicide) mechanism paraquat is reduced and oxidized in cycle, between microsomal cytochrome C reductase and oxygen, superoxide radicals become H2O2, H2O2 Fe hydroxyl radicals --> membrane lipids --> lipid peroxidation --> (lung) tissue damage --> inflammation --> fibrosis, paraquat (bipyridyl class of herbicide) treatment cholestyramine prevents CAH reabsorption, paraquat (bipyridyl class of herbicide) treatment 100% O2 is contraindicated because more radicals produced